Who Benefits? Exploring Moderators of Response to Intervention Among Depressed and At-Risk Youth

CE Credit: 2

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Length: 110 minutes

***No slides made available by presenters***

Session offered by Divison 53.

Results of numerous trials support the efficacy of antidepressant medication and specific psychotherapies (CBT, IPT) for the treatment of child and adolescent depression. More recently, evidence suggests that psychosocial approaches are also efficacious for preventing depression among at-risk youth. Despite success at identifying effective interventions, data from these trials suggest that not all youth benefit. There has been limited progress at identifying robust predictors of response or moderators indicative of differential response to specific therapeutic or preventive interventions. The presentations in this panel will summarize moderator analyses in recent treatment and prevention trials with the goal of furthering a research agenda on personalization of interventions. The first presentation (Dr. Rohde) will present findings from a school based cognitive behavioral preventive intervention trial, where moderators examined included negative life events, social support deficits and substance use. The second presentation (Dr. Garber), also a cognitive behavioral prevention program, examined the role of both familial (parental depression) and individual (e.g., comorbid symptoms) level moderators on response to intervention. The third presentation (Dr. Curry) will summarize moderators of response to CBT, SSRI antidepressant medication, and combination therapy in the multi-site Treatment of Adolescent Depression Study (TADS), including moderators of acute response as well as moderators of longer-term outcomes (e.g., depression, substance abuse problems, and other outcomes at longer-term follow up). The final presentation (Dr. Mufson) will examine sociodemographic and illness characteristics as moderators of response to treatment with Interpersonal Psychotherapy for Adolescents (IPT-A) and discuss these results in the context of the literature on moderators of response to evidence-based psychotherapies. Discussion will focus on the implications of this work for guiding future research and intervention efforts, including the development of targeted approaches for refractory groups and the development and testing of personalized approaches for matching individuals to interventions with the greatest likelihood of benefit.

Learning Objective 1
Recognize factors that may moderate an individual's response to a depression treatment or preventive intervention.

Learning Objective 2
Identify issues relevant to the design, testing and implementation of personalized approaches to adolescent depression.

Presenters: Amy Goldstein, PhD (Cochair); Joel Sherrill, PhD (Cochair); Paul Rohde, PhD; Judy Garber, PhD; John F. Curry, PhD; Laura Mufson, PhD